Association of the DNA repair genes polymorphism with the frequency of chromosomal mutations and health status of the population of the Almaty region

The study utilized molecular-genetic, cytogenetic, and statistical analyzes methods. A cytogenetic molecular genetic analysis of the inhabitants villages Amangeldy, Belbulak, in whose territory warehouses unused pesticides are located, was carried out. Residents Basshi village, on which there no products disposal pesticides, were taken as control. Cytogenetic showed a high level chromosomal aberrations for Belbulak an increased Amangeldy village low cohort. Molecular did not reveal significant correlation between polymorphisms XRCC1 Arg194Trp, XRCC3 Thr241Met XPD Lys751Gln genes frequency aberrations. However, determined associative relationship polymorphism DNA repair gene Arg399Gln with development cardiovascular diseases population living near foci pesticidal contamination.